Adult-onset idiopathic hypogonadotropic hypogonadism: possible aetiology, clinical manifestations and management.
نویسندگان
چکیده
Correspondence to: Dr Xue-Yan Wu, Department of Endocrinology, Peking Union Medical College Hospital, Beijing 100730, China. Fax: +86-10-6529-5073 E-mail: [email protected] Received: 8 February 2010 Revised: 8 March 2010 Accepted: 25 March 2010 Published online: 7 June 2010 Letters to the Editor Asian Journal of Andrology (2010) 12: 611–614 © 2010 AJA, SIMM & SJTU All rights reserved 1008-682X/10 $ 32.00 www.nature.com/aja
منابع مشابه
Adult-onset idiopathic hypogonadotropic hypogonadism--a treatable form of male infertility.
BACKGROUND Men with isolated gonadotropin-releasing hormone (GnRH) deficiency typically present with an absence of pubertal development. We describe an adult-onset form of idiopathic hypogonadotropic hypogonadism that develops after puberty. METHODS We studied 10 men (age, 27 to 57 years) with normal sexual maturation, idiopathic infertility, sexual dysfunction, low serum testosterone concent...
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Mutations in the GnRH receptor (GnRH-R) gene have been reported to cause idiopathic hypogonadotropic hypogonadism (IHH). Herein, we describe a 26-yr-old male with a mild phenotypic form of IHH, the fertile eunuch syndrome (IHH in the presence of normal testicular size and some degree of spermatogenesis), associated with a homozygous mutation (Gln106Arg) in the GnRH-R. This mutation, located in ...
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Idiopathic hypogonadotropic hypogonadism (IHH) with anosmia (Kallmann syndrome; KS) or with a normal sense of smell (normosmic IHH; nIHH) are heterogeneous genetic disorders associated with deficiency of gonadotropin-releasing hormone (GnRH). While loss-of-function mutations in FGF receptor 1 (FGFR1) cause human GnRH deficiency, to date no specific ligand for FGFR1 has been identified in GnRH n...
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ورودعنوان ژورنال:
- Asian journal of andrology
دوره 12 4 شماره
صفحات -
تاریخ انتشار 2010